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Yi-Qiang
(Eric) Cheng
Assistant Professor
Biological Sciences, UWM
Phone: (414)
229-4739
Fax: (414)
229-3926
E-Mail:
Web
Site: Biological
Sciences Page
University of Wisconsin-Milwaukee
Lapham Hall, 131C
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Research Interests
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My
lab is designed to develop new methodology and technology for the discovery
and engineering of pharmaceutically relevant microbial natural products
as drugs or drug leads. Initial research will focus on:
| 1) |
The study of molecular genetics of homologous DNA recombination
processes in actinomycetes, to develop a set of tools and
methodology for the improvement of homologous DNA recombination
frequency in actinomycetes for engineered biosynthesis of
novel drug analogs;
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| 2) |
Microbial biodiversity in the Great Lakes. Natural product
biosynthesis and drug discovery in marine and freshwater
microorganisms;
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| 3) |
The development of computational algorithms to survey microbial
genome sequence data for the prediction of metabolic potential. |
The long-term goal is to apply the methodology and technology obtained
from the pilot studies for large-scale discovery and development of
human and veterinary medicines.
See
Dept
of Biology Page for more information.
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Education
| • | Ph.D., Michigan State
University, 1999 |
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| • | PDF, University of California
- Davis, 1999-2001 |
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| • | PDF, University of Wisconsin
- Madison, 2001-2003 |
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Selected Publications
| • | Tang, G.-L*., Cheng, Y.-Q*.
and B. Shen. (2004) The biosynthetic gene cluster of the antitumor antibiotic
leinamycin from Streptomyces atroolivaceus S-140 revealing unprecedented
architectural complexity for a hybrid polyketide synthase and nonribosomal
peptide synthetase. Chem. & Biol. 11:33-45. |
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| • | Cheng, Y.-Q*. Tang, G.-L*
and B. Shen. (2003) Type I polyketide synthase requiring a discrete acyltransferase
for polyketide biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 100:3149-3154
(Highlighted by a Commentary). |
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| • | Cheng, Y.-Q. Tang, G.-L.
and B. Shen. (2002) Identification and localization of the antitumor macrolactam
leinamycin biosynthesis gene cluster from Streptomyces atroolivaceous S-140. J.
Bacteriol. 184:7013-7024. |
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| • | Ahn, J.-H., Cheng, Y.-Q.
and Walton, J. D. (2002) A refined physical map of the TOX2 locus of Cochliobolus
carbonum required for cyclic peptide biosynthesis. Fungal Genet.
Biol. 35:31-38. |
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| • | Cheng, Y.-Q. and Walton
J. D. (2000) A eukaryotic alanine racemase gene involved in cyclic peptide
biosynthesis. J. Biol. Chem. 275, 4906-4911. |
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| • | Cheng, Y.-Q., Ahn, J.-H.
and Walton J. D. (1999) A putative branched-chain-amino-acid transaminase
gene required for HC-toxin biosynthesis and pathogenicity in Cochliobolus
carbonum. Microbiology 145, 3539-3546. |
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| • | Cheng, Y.-Q., Le, L. D.,
Walton, J. D. and Bishop, K. D. (1999) 13C labeling indicates
that the epoxide-containing amino acid of HC-toxin is synthesized by head-to-tail
condensation of acetate. J. Nat. Prod. 62, 143-145. |
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| • | Scott-Craig, J., Cheng,
Y.-Q., Cervone, F., de Lorenzo, G., Pitkin, J. W. and Walton, J. D. (1998)
Targeted mutants of Cochliobolus carbonum lacking the two major
extracellular polygalacturonases. Appl. Environ. Microbiol. 64,
1497-1503. |
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